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1994-08-20
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Document 0643
DOCN M9480643
TI Impact of HIV infection on non-AIDS mortality among Italian injecting
drug users.
DT 9410
AU Zaccarelli M; Gattari P; Rezza G; Conti S; Spizzichino L; Vlahov D;
Ippolito G; Lelli V; Valenzi C; Drug Treatment Centre and AIDS Unit
USL-RM10, Rome, Italy.
SO AIDS. 1994 Mar;8(3):345-50. Unique Identifier : AIDSLINE MED/94304555
AB OBJECTIVES: To estimate the excess mortality of injecting drug users
(IDU) stratified by HIV serostatus compared with the general population
in Italy. To compare total and cause-specific mortality in HIV-positive
versus HIV-negative IDU, in order to identify possible HIV-related
non-AIDS causes of death in this population. METHODS: All IDU attending
two drug-treatment centres in Rome who underwent HIV testing between
1985 and 1991 were enrolled into a prospective study. The end-point of
the study was death from any cause by 31 December 1991. Mortality rates
were compared using age-adjusted standardized mortality ratios and
person-time techniques. RESULTS: Of the 2431 IDU, 1661 (68.3%) were
HIV-seronegative and 82 seroconverted. Of 181 deaths, comprising 89 from
AIDS and 92 from other causes, the mortality rate was 4.5 and 0.8 per
100 person-years in HIV-seropositives and HIV-seronegatives,
respectively. For non-AIDS mortality in HIV-seropositives, the overall
rate was 1.7 per 100 person-years. Deaths from overdose and
endocarditis/embolus tended to be higher in HIV-seropositive than
HIV-seronegative IDU, although there was no difference in the rate of
deaths due to pneumonia by HIV serostatus. CONCLUSIONS: These data are
consistent with other studies demonstrating a higher frequency of
mortality among HIV-seropositive IDU. The excess in overdose mortality
among HIV-seropositives is disturbing and merits further investigation.
DE Adult Cohort Studies Female Human HIV Infections/*COMPLICATIONS HIV
Seronegativity HIV Seropositivity/COMPLICATIONS Male
Overdose/COMPLICATIONS/MORTALITY Prospective Studies Rome/EPIDEMIOLOGY
Substance Abuse, Intravenous/*COMPLICATIONS/*MORTALITY Support,
Non-U.S. Gov't Survival Analysis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).